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Gout Dugout.Issue #069. alzheimer's disease and gout | the best gout diet study,
March 30, 2015

Hello and Welcome to the March (Spring) 2015, edition of the Gout Dugout newsletter. The Gout Dugout is the 10 minutes' read from that gives you useful ideas that may help with your gout.

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ALZHEIMER’S DISEASE AND GOUT > Does gout protect against Alzheimer’s disease?

There had to be something good about gout !

Gout sufferers in earlier centuries thought that if you got it you wouldn't get something else. I suppose this optimistic speculation was a consolation for the suffering. The idea would not have been proved, but just lately there has been interesting news about Alzheimer’s disease and gout. And this has come closer to a proof.

Researchers in the U.S. and Canada analysed over 3.7 million British medical records from 1995 to 2013. Researchers found 309 new cases of Alzheimer’s in 59,224 gout sufferers, but 1,942 in 238,805 non gout sufferers. over a 5 years (median figure) follow-up.

From this, and screens for lifestyle, sex and others, they calculated that those with gout had a 24% lower risk of getting Alzheimer’s disease than those without gout.

In gout therapy we always talk about getting uric acid down, down, down. The lower the better. And we talk about it as if it’s poison just because it can crystallise and cause a nasty, very painful condition.

But it is actually a powerful anti-oxidant (destroys free radicals), including, it is speculated, in the brain. So it’s thought uric acid protects brain cells from degenerating.

Therefore gout patients with higher uric acid actually protect their brain which could be why gout patients are at lower risk for Alzheimer’s. The condition did not apply to those with osteoarthritis, but then osteoarthritis is not a uric acid related condition.

This probable connection raises the question that very low levels of uric acid in the blood e.g. 2.5 mg/dL or lower (and maybe a little higher than that too), might even accentuate Alzheimer’s or another neurodegenerative disease. It’s going to take a number of studies to sort this out.

Said a leading researcher Dr Hyon Choi: “This is just an initial finding. One paper doesn’t make science.”

Note that this finding is only a possible lower risk, it's not a 100% guarantee that you won’t get Alzheimer’s if your uric acid is high and you have gout. More research is needed and I am sure we'll get it.

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Every so often I like to say something in the Gout Dugout about my favourite gout diet study. New readers arrive who probably have never heard of this study., so if you've read this before please bear with me.

The website page that describes this study only amounts to under 0.5% of all page views on the website at present. So many visitors – too many visitors – do not see it and have never heard of it. But everyone wants a dietary cure for gout, if they can achieve it, and the less trouble it is, the better.

This was a diet study of people with gout – and there aren’t very many such studies – where the participants ate many of the so-called “wrong” things – they ate meat, and they ate fish and they drank wine !

It was conducted in South Africa about 15 years ago. Their dietary regimen was based on Dr.Barry Sears’s Zone diet (Enter The Zone).

Despite these “wrong” foods, their uric acid levels fell, and so did the frequency of their gout attacks (flares) over one year. They actually achieved what so many gouty people hope can be done by a diet.

One drawback was that there were not a large number of participants, but this study is widely quoted in scientific gout literature.

Read our page about this study. On this page there is a link to the British Medical Journal (BMA) online where you can download this study free. It is called > Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study


Our fructose and gout pages benefited from the experience of Tony Phylactou. He has also placed a video about finding a gout remedy on YouTube after a long search. The long search for a remedy to control gout is a fairly typical gout story. Gout salvation came for him when he realized that his cause of gout was fructose – the sugar in fruit, and it's also half of a table sugar molecule.
See his gout success video here

Three years have passed since his last gout attack he tells me. Good going, but not yet in the clear.

About one in five gout sufferers has kidney stones. Get rid of them naturally if you can. Click on the banner ad

Kidney Stone Natural Treatment


Some of the new gout drugs under development took a step forward in the past three months since the last issue. The European Medicines Agency has said it will consider Lesinurad for marketing approval in the EU, but as yet no word from the U.S. FDA about it.

Arhalofenate which reduces uric acid and fights flares, (without having to use colchicine), competed its phase 2B study to its developers (CymaBay Therapeutics) satisfaction. Its flare rate at a 800 mg dose was 46% better than allopurinol which is quite good but not startlingly so. Arhalofenate has now been through 5 studies and CymaBay hope to start phase three trials early next year.

And Bucillamine (REV-002) will go into new phase 2 trials.

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There are now two pages about the Mediterranean diet for gout, which is believed to be a good diet for gout sufferers. Perhaps a better way of putting it, is to say Mediterranean type foods are good for gout but many of these are eaten anyway in Europe and North America, that is in other food traditions. Find out what these foods are. Link to the Mediterranean diet for gout, page 1.

And there’s a new page about nuts and gout. Can gout sufferers eat nuts ? I'd say Yes, at least for those nuts (quite a number) for which I was able to find their purines’ amounts.


Back in 2009 I wrote about the discovery of a gene that causes gout. When this gene behaves normally, ABCG2 produces a protein that transports urate (uric acid) from the kidneys and intro the urine as opposed to URAT1 and other transporters which takes it back into blood. But when it doesn't, findings were that only half the normal amount of uric acid is excreted. Hence blood uric acid rises, and you know what that means.

A few years after, another malfunctioning gene, this one called SLC2A9, also adversely affected uric acid excretion.

Now a very big study in Japan - I've never seen so many researchers on the credits' list (about 40) - has thrown some more light on this developing line of gout enquiry.

Around 2,900 Japanese were studied - 1,600 with gout, and 1,300 without. Researchers found an elevated risk of gout in people who have gene variations that reduce the kidneys,' or the intestines' ability, to excrete uric acid or dissolve uric acid. i.e. genetic variations from the genetic norm, cause gout.

Expect much news over the coming years about genetic causes of gout. The research may lead to drugs one day.


Use's search box, located towards the bottom of the Home Page, to find site references to any word you enter into it. It is a good way to find out where and what the site has to say about any gout topic. For example, want to know more about Rasburicase? Type that in the site search box.

There are currently around 225 pages, including all the back issues of this newsletter. It works. Use it!

Next issue in JUNE.

Thanks for reading, all the best of health.

John Mepham BA (Econ)
Makati City,

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