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Gout Dugout.Issue #082 | using more gout remedies | lowering seafood purines | sardines for gout |
July 02, 2018
Hello and welcome to the Summer 2018 edition of the Gout Dugout newsletter. The Gout Dugout is the 10 minutes' read from www.best-gout-remedies.com that gives you useful ideas that may help you with your gout. Copy and print if you prefer to read a version on paper. If you are extra busy now you could bookmark it for later.
Best-gout-remedies.com has a page about pantothenic acid for gout and to date there are a couple of testimonials from gouty people who have used it and think it could have helped them. Experts recommending it include Dr.Robert Atkins of the Atkins diet.
Unlike Vitamins C and E, and fish oils, pantothenic acid (B5) is not exactly one of the best known vitamins. Few have heard of it. And even fewer know that it has been touted by experts as a remedy for gout since it is thought to dissolve uric acid and thus lower its blood level.
The other day I had a new testimonial for it. Someone whose gout returned after a 5 year absence (not unusual) took pantothenic acid along with folic acid (B9), cherry capsules, quercetin and B vitamins. B vitamins work better if taken together.
Our correspondent took the calcium pantothenate version of pantothenic acid. That is the version recommended by diet doctor Dr.Atkins, in his Dr.Atkins Vita Nutrient Solution book. His dose was 200-250 mg twice a day (breakfast and dinner: 100 – 125 mg each time). That's half the amount Dr. Atkins recommended but our correspondent reports success with this dose, but he used a different formula to the Atkins one. And it may have worked alone.
We can't conclude pantothenic acid alone helped his gout attacks. Because he also took folic acid which is also thought to lower uric acid. And because he also took quercetin for which there is now one study among humans which showed it lowered uric acid in that study by 8% in one month. Again our correspondent took the right type with bioflavonoids and rutin. Rutin too has lowered uric acid in a rats study.
And he took another gout nutrient – our old friend cherry capsules - twice a day. One, some, or all of these could have helped him. And there was more.
He took more B vitamins – B6 and B12. And finally he took choline, inositol and Krill oil. The latter for its omega 3 to lower the consequent inflammation of an attack. It does not lower uric acid.
What impressed me about this protocol (formula) is that it’s all natural and comprehensive. He increased his odds of success by taking FOUR nutrients (five if we count Rutin) reported by individuals and a few experts, to help lower uric acid. That is the key to controlling gout.
But if you use someone's formula for gout, stay exactly with that.
The other lesson for us, a useful reminder, is he had his gout attack 5 years earlier and assumed his gout had gone away. Many people do. But if you are not correctly watching what you eat and drink, and achieving other things to control it, such as taking the right medicines and nutrients and losing weight if necessary, another attack in the future is just about certain.
He rightly thought two work factors – insufficient hydration and long outside working hours, contributed to the return of gout.
I think I promised in the last edition there would be more on lowering food purines before eating food.
There is a new page called lowering seafood purines. It's really a summary of the not-so-many-studies there have been about lowering the purines in fish. In some cases all the four purines bases are analysed, both the ones that raise uric acid and the two that don’t (or not much).
Main points - In a small number of studies rinsing lowered fish purines by a considerable amount as it did in the minced beef study. Enough to make a 5-10 minutes rinse worthwhile Boiling (stewing) and frying fish were the two top ways of lowering seafood purines by cooking.
A new page on the website about lowering seafood purines includes one study where fresh sardines (not canned, they have been cooked already) were boiled for 25 minutes and that lowered their nucleic acids (the precursor of purines) by nearly 50%.
The silvery sardine
Fresh sardines are difficult to find these days but I think sardines are an interesting fish. They are good for gout because of their high levels of omega fats and many other nutrients but bad because of their high amount of purines, so boiling them first seems like a good idea. if you can get them. I guess you can boil canned ones but that wasn't in the study. Should have the same effect though
Visit sardines and gout
We recently had the latest news from SEL 212, the new gout drug under development in the United States that will eventually, should it be approved, compete with Krystexxa. It is for chronic gout patients, not an average one. It is now towards the end of its Phase 2 trials with only the phase 3 trials to come before concluding them. Phase 3 begin later this year
SEL-212 is two drugs in one. Its Pegsiticase (Uricase Peg-20) lowers uric acid and its SVP-Rapamycin mitigates the response from the immune system. Whereas Krystexxa (pegloticase) is a form of uricase with no second drug added to mitigate immune system responses.
Results It continued to deliver solid results. Selecta reported 81% of trialists controlled their uric acid below 6.0 mg/dL at week 12. Whereas in a Krystexxa trial at week 16 about half did. Similarly there were fewer gout flares in the SEL-212 trial than in an earlier Krystexxa one.
But there are only 27 trialists so far in the SEL-212 trial to compare which isn't a lot.
Selecta have not reported how much uric acid fell in patients it tested. So we really don't know yet if the results were brilliant or not. Krystexxa lowered uric acid 7.0 mg/dL in the first week in one batch of trialists, an excellent reduction.
Click on this advert, underneath, if you want more information about the Kidney Stones Removal report - kidney stones are related to gout
THE WEBSITE'S GOUT TOPICS PAGE
Ever get the feeling there is a gout topic you need to know about? Read on ! Last but not least, there is another new page on the website, this one named gout-topics-list. It is intended to help visitors see what is on the whole site on a single page. Every page is listed.
Until now that wasn't possible, (except to a small extent on the home page). You had to have a search term in mind and use that in a search box.
You can do a search on this gout topics page too by using your find function. Or you can simply scroll down noting page names.
The only website pages that are not listed here are the 81 back issues of this newsletter. But there is a link to the newsletter back issues page where you can see their contents.
The list of page topics grows by the month so pop over there to update yourself too. Bookmark those you may wish to view later To take a look click on the link below.
If you are not a subscriber to the Gout Dugout, this free gout newsletter, you can sign up at this page - click on the link below.
Back Issues for The Gout Dugout Newsletter
Go to the www.best-gout-remedies.com home page by clicking on this link.
WEBSITE TIP - YOU CAN SEARCH FOR ANSWERS
Use www.best-gout-remedies.com's search box, which is located towards the bottom of the Home Page, to find site references to any word you enter into it.
It is a good way to find out where and what the site has to say about any gout topic. For example, want to know more about Krystexxa for gout? Type Krystexxa in the search box.
There are currently around 270 pages, including all the back issues of this newsletter. It works. Use it!
The next issue - Autumn (Fall) 2018, end September.
Thanks for reading and all the best of gout free health.
John Mepham BA (Econ)
I am pictured here with my Filipina wife who helps me with my gout researches for this website. In 2006 it was her belief that she had gout that began my enquiries into "the disease of kings." However, as it turned out, she happily did not !
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